A very common anti-androgen that is often used in addition to estrogen. It's a pill form swallowed once or twice daily.

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How to take

Take a once or twice daily pill. We recommend not taking this late in the evening because it can cause increased urination.

Potential side effects

Spironolactone is a diuretic (water pill), so it may lower your blood pressure and make you urinate more. You should consider drinking more water or eating foods with salt if you feel dizzy, faint, or dehydrated. Too much spironolactone can cause kidney, electrolyte (potassium) and heart arrythmias, as well as psychiatric problems

Is spiro right for me?

Very effective at decreasing testosterone levels. Relatively inexpensive. As a diuretic, it can make someone have to pee frequently. This can lead to lower blood pressure, fatigue, and dehydration. Can increase potassium levels in the blood, especially in those with kidney issues -- very rarely this can lead to dangerous changes in heartbeat.


Calcium Sulfate Dihydrate (UNII: 4846Q921YM)
starch, corn (UNII: O8232NY3SJ)
Hypromelloses (UNII: 3NXW29V3WO)
magnesium stearate (UNII: 70097M6I30)
Povidone, Unspecified (UNII: FZ989GH94E)
titanium dioxide (UNII: 15FIX9V2JP)
Peppermint (UNII: V95R5KMY2B)
Ferric Oxide Red (UNII: 1K09F3G675)
Ferric Oxide Yellow (UNII: EX438O2MRT)
Ferrosoferric Oxide (UNII: XM0M87F357)
Polyethylene Glycol, Unspecified (UNII: 3WJQ0SDW1A)

If you’re looking for specific ingredients due to allergies, it's always best to reference the documentation that accompanies your refill as it will be fully accurate to the medication you have in hand. If you have any questions please reach out to our team so we can help ensure your safety.

Popular Questions

I've heard it has a lot of side effects, is that true?

The common side effects are increased urination and some changes to blood pressure that can cause dizziness. However, at the doses that we prescribe, side effects are uncommon.

People told me it doesn't work very well. Is that true?

Spiro is incredibly effective at lowering testosterone. However, there are other ways to lower testosterone such as increasing your estrogen dosage. This is something you can talk with your clinician about.

Can I just take Spiro?

It is not that common but some people do just take Spiro. This is also something you can talk with your clinician about.

Do I need to take Spiro to block my testosterone?

You do not as higher doses of estrogen are very good at lowering levels of testosterone in your body.

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