9 Myths You Might Have Believed About Estrogen HRT

With so many misconceptions about hormone replacement therapy and transitioning, it’s hard to get reliable information. If you are considering taking estrogen, here’s what you need to know.

May 11, 2022
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Illustrations by Rory.

This article was clinically reviewed by Jess, DNP. This article was updated on 7/20/23 by the FOLX Editorial Team.

Even though gender-affirming hormone therapy has been around for nearly 100 years, there are still many misconceptions about the effects of HRT on transgender people. When you realize most of what the general public (and the medical profession) knows about transgender and nonbinary people comes from the media—it’s no wonder that we often know more about our bodies than most medical providers do. We’ve all seen the misrepresentation where a girl misses one dose of estrogen and is suddenly seconds away from becoming a hormonal wreck. The fear of transgender people medically transitioning runs deep in our collective conscience.

"I really was afraid for the longest time to come out. I did a lot of my own research prior, but I didn’t feel as if I had the proper information."

Luna spoke to us about the apprehension she had before starting HRT. “I really was afraid for the longest time to come out. I did a lot of my own research prior, but I didn’t feel as if I had the proper information. One of the biggest misconceptions I had before starting estrogen was that it is an irreversible process.” While there are certain changes that are permanent, HRT is not a "life sentence." Everyone’s experience on HRT is unique and varied. While some people might experience nuanced and subtle emotional, physical, and psychological changes, there are many misconceptions that people believe are automatic outcomes of taking hormones. So before you get lost on a forum on the deep web reading horror stories about estrogen HRT, read our article. We’ve compiled a list of the top 9 myths that are out there about E (estrogen) and worked with our trusted clinical team to explain each one. We want to make sure that you are empowered with factual, evidence-based information on estrogen and what changes you can (and can’t) expect on HRT.

1. Taking estrogen means you will be hysterical and emotionally out of control.

If the sexist tropes of a cisgender woman on her period weren’t enough to make you cringe, there are even more (incorrect) stereotypes about transfeminine people on E. The idea that estrogen is a hysteria-inducing force that will make any transfeminine person break down over something as trivial as a broken nail, is, well, false. While some people do experience changes in their emotional landscape, these hyperbolic stereotypes usually come from a deep belief that views women (and femininity) as emotionally labile and "dramatic."

It’s natural to be worried about how and if your emotional experience of the world will change. One of our FOLX clinicians, Dr. Kameryn, has practiced gynecology for 17 years and thus spent her whole career discussing estrogen. Dr. Kameryn weighs in on this myth. “Every cisgender woman and trans person on estrogen would be incredibly insulted by the notion that estrogen makes people hysterical. While hormonal fluctuations can cause mood changes in some people, research studies consistently show that gender-affirming hormones improve mood and mental health for trans people.” 


For many, taking estrogen allows them for the first time to actually feel their feelings, perhaps emotions that were always there but remained buried.

This can often be experienced as a welcome change from the numbness that many transgender women report feeling before going on hormones. Jess, DNP, weighs in: "A lot of my members have some concern about how beginning GAHT may affect their mood, but the majority of them report feeling an overall improvement in their mood and outlook after starting these medications.”

2. You will lose your sex drive or libido.

Sex drive is a highly individualized and relative thing. It’s important to know that no one truth applies to the connection between libido and HRT. Some people experience changes in sexual drive, but this is more likely due to decreased testosterone levels due to testosterone blockers. Everyone has a different response to hormones, so it’s important to know that your desires or what gets you sexually aroused might change as a result of taking estrogen, the same way these things might shift and change due to other circumstantial factors in our lives. No matter what, you can always talk to your healthcare provider if this is something you experience.

3. You won’t be able to get someone pregnant.

This is a common misconception that many people have before starting HRT. It’s important to know that hormone therapy is not an effective form of birth control. You can still get people pregnant, even while on estrogen. Make sure to use condoms and other forms of birth control if you are having the type of sex (i.e., penis penetrating a vagina/front hole) that can result in pregnancy.

4. You will lose your ability to have biological kids.

While estrogen HRT can decrease your fertility, the truth is, the medical community doesn’t have any real and meaningful data on the long-term impact of estrogen HRT on transgender women and transfeminine people’s ability to have biological children. Courtney, one of our nurse practitioners, says, “I have heard cases where people on HRT go on to conceive after being on hormones for some time. I like to advise members that hormone use could potentially impact their ability to conceive using your own genetic material, but there are ways to preserve sperm prior to starting estrogen.” If this is something that’s important to you, be sure to discuss it with your FOLX clinician.

5. You will get blood clots and have strokes if you take estrogen long-term.

This is a big fear that our clinical team hears often from folks who want to start estrogen HRT but are worried about the health risks. A recent study found that while the rate of blood clots for transgender women on estrogen was higher than in the general population, rates of blood clots are lower in transgender women compared with premenopausal cisgender women taking oral contraceptives. In short, estrogen HRT can increase the risk of blood clots--but no more than birth control pills do. While the chance of developing a blood clot or having a stroke is low, it’s important to know that some people are at an increased risk (such as people who smoke or have a history of heart disease or clotting disorders).

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6. Estrogen will change your voice.

Estrogen will change many things, but unfortunately, vocal cords aren’t one of them. If you were assigned male at birth (AMAB) and weren’t on hormone blockers as a teenager, testosterone would have thickened your vocal cords and deepened your voice. If altering your voice is important to you, voice therapy is always an option. If you're looking for a more permanent change, surgical options are available as well.


7. Estrogen will make you shorter or your feet or hands smaller.

Bone structure is something that cements during our first puberty, so—unless you took hormone blockers as a young person—taking estrogen later in life shouldn’t affect things like height or shoe size. This being said some people might notice changes due to muscles, tendons, and ligament alterations which can subtly change the shapes bones are pulled into. Estrogen will not eliminate hair growth, though it may affect the texture and reduce the thickness of your facial and body hair.


8. You have to tell people the second you start taking estrogen because everyone will notice.

Many transfeminine and nonbinary people put off starting estrogen because they aren’t ready to come out to the world. There is often a belief that once you start hormones, somehow everyone will suddenly know. We are here to tell you that this isn’t true. Sometimes, people may notice something different about you, but often can’t quite put their finger on it. Many people decide to start estrogen HRT and then tell people once they are ready. The reality is that HRT is a gradual process that changes things slowly, day by day. You don’t have to tell anyone that you are on hormones unless you want to.

9. HRT is an irreversible process and linear experience that you have to commit to for life.

It’s a common experience to get caught up in the ‘what-ifs’ of starting hormone therapy. It can be difficult to sort out what is internalized transphobia and what is genuinely the right decision for you. Luna told us, “I just wish I would have started sooner and not let fear stop me. It’s a slow and gradual process, and you'll be much happier if it is something you truly want.” 

The most important thing to remember is that you are in control of your relationship with your body. Some people take a low steady dose forever, while others take a higher dose for a while and then stop or have periods on and off estrogen. Hormones are just one part of some people’s transition. It’s your gender and, ultimately, your decision for what path you take. It’s always best to talk with your provider to understand which effects are more permanent and which ones are reversible, but either way, just know that your transition is in your hands. 


For those ready to get started with FOLX for estrogen, sign up for a virtual visit with one of our gender-affirming clinicians in just a few days. For existing FOLX members with clinical questions about estrogen, reach out to your FOLX Care Team. And for those who want to know more or have general questions, read up on estrogen in the Library or reach out to us directly at the FOLX Help Center.

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FOLX Health is the first digital healthcare company designed by and for the LGBTQIA+ community. Our services include virtual primary caregender-affirming hormone therapy including estrogen and testosterone (HRT), mental health care, sexual and reproductive health carepreventive care, and fertility consultations. FOLX memberships give you access to LGBTQIA+ expert clinicians, peer support, thousands of LGBTQIA+ resources, and more. Whether you’re lesbian, gay, bisexual, transgender, queer, gender non-conforming, or nonbinary, you can find LGBTQIA+-specialized health care that helps you meet your wellness goals. FOLX Health is health care that's queer all year. Get all the benefits of becoming a FOLX member and sign up today!

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