Testosterone Routes Offered by FOLX

Each individual body has its own best route and dosage of receiving Testosterone HRT.

Person deciding testosterone HRT route

Whether someone is just starting Testosterone hormone replacement therapy (HRT), or has been on it and is looking for a different route, FOLX has two options to choose from: injections and gel. With each of those routes, there are different dosage levels that can result in slower or quicker physical changes, depending on personal preference (more on low, average, and high dose physical effects here). There are pros and cons to each method, and it’s really up to what feels best for someone’s body and mind. And don’t worry, routes can always be changed.

Injections

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A weekly, or every other week, self-administered injection of testosterone. There are two injection methods: Intramuscular (into the muscle) and subcutaneous (into the fatty tissue under the skin).

There are two different types of injectable testosterone: testosterone cypionate and testosterone enanthate. The most common injectable testosterone used in the US is testosterone cypionate, so that is the one we usually initiate for people wanting an injectable route.

There are a few key differences between testosterone cypionate and testosterone enanthate: Enanthate is suspended in sesame oil, whereas cypionate is suspended in cottonseed oil. Cypionate has a slightly slower release and longer active life (meaning it can be dosed every two weeks). And between the two, there can be a difference in cost.

Both enanthate and cypiontate are slow-acting testosterone esters with a release time between 10-14 days (so some people decide to inject every 2 weeks instead of weekly).  

Common pros & cons of injectable testosterone:

PROS CONS
Testosterone cypionate, in particular, is the most relatively affordable option Not everyone feels comfortable giving themselves a shot!
Being weekly or biweekly medication, it’s not something to remember every day Injections can be a bit uncomfortable or painful for some
Some people feel they notice faster changes using injectable Testosterone Some people don’t like the peaks and lows that they feel on a weekly or biweekly medication--they may start to feel lower energy/lack of testosterone as they get to the end of their week
Good option for people who have skin sensitivity to gels or patches. Some people worry about storing their injection supplies and keeping them safe from kids or other people who they don’t want to have access to needles.

Injectable testosterone dosage levels:

Injectable Testosterone
Low Dose 0.1mL (20mg of 200mg/mL) weekly
Medium Low Dose 0.2mL (40mg) weekly
Average Start 0.3mL (60mg) weekly
Maximum Dose 0.5mL (100mg) weekly or 1mL (200mg) biweekly

Transdermal Gel

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Gel that is rubbed onto the skin daily, allowing testosterone to be absorbed through the skin and into the bloodstream. The gel is applied gently onto the skin so it can absorb -- the areas with less body hair work better: inner thighs, belly, inner arms. FOLX offers testosterone gel in a pump bottle that comes in varying strengths and volumes to correspond to preferred dosage to leave out the guessing.

Common pros & cons of transdermal gel

PROS CONS
Good option for people who are scared of needles or who do not like the idea of self-injections T gel can get transferred to another person’s skin with any skin-to-skin contact, and needs a few hours after application to be fully absorbed before any skin-to-skin contact should happen with another person (or else it could be absorbed by the other person’s body)
Steady daily dose of testosterone (fewer highs and lows than injectable) Gel can wash off in the shower / bath or swimming and requires a few hours to absorb before doing either
Can be more expensive than injectable route

Transdermal gel dosage options:

Transdermal Testosterone
Low Dose 20mg daily
Average Start 50mg daily
Maximum Dose 100mg daily

With the different routes and dosages of testosterone, there are a lot of ways to find the one that fits best for each individual body. For those ready to get started with FOLX for testosterone, the process begins here. For existing FOLX members with questions about route or dosage, don't hesitate to schedule time with a clinician. And for those who’ve just got some more questions, read up on testosterone here, and feel free to reach out to us at thelibrary@folxhealth.com.